Clinical Pharmacology of Rocuronium Bromide

The pharmacology of rocuronium bromide

Rocuronium is a new nondepolarizing neuromuscular blocking drug. Its onset of action is comparable to that of succinylcholine, with good-to-excellent intubating conditions possible 1 minute after doses two times the ED95 (600 pg/kg). The ED9a of rocuronium is essentially the same for children as for adults. Its duration of action is similar to vecuronium, and it is shorter for children than for...

Rocuronium Bromide Versus Vecuronium Bromide

BACKGROUND: Rocuronium Bromide is a newer, low potency nondepolarising neuromuscular blocking agent. It is proven to be five to seven times less potent than vecuronium.The aim of the present study was to evaluate the effectiveness of 2ED95 (2 times effective dose 95) dose (0.6mg/kg) of rocuronium with regard to onset time, the intubating conditions and the duration of action and to compare it w...

Pain on injection of rocuronium bromide.

[Suicide by intravenous injection of rocuronium-bromide--case report].

Suicides by intravenous injection of an overdose of medicaments are uncommon. In this paper, we present the case of a suicide by rocuronium-bromide injection in combination with an oral overdose of metoprolol. Unfortunately, in Belgrade, there is no toxicological laboratory capable of detecting rocuronium. The interpretation of autopsy and toxicological data in this case was made difficult due ...

Rocuronium bromide induced anaphylaxis in a child -A case report-

Anaphylaxis or anaphylactoid reaction in pediatric patient during anesthesia is rare. We report a rocuronium induced anaphylactic reaction in a 33-month-old female. The patient was scheduled to undergo escharectomy due to injuries suffered from a major burn. Shortly after administration of rocuronium, the patient developed severe hypotension, tachycardia, and hypoxia. A similar reaction occurre...